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por Randy O. Wayne

Plant Cell Biology is a semester long course for undergraduates and graduate students which integrates mathematics and physics, two years of chemistry, genetics, biochemistry and evolution disciplines. Having taught this course for over ten years, the author uses his expertise to relate the background established in plant anatomy, plant physiology, plant growth and development, plant taxonomy, plant biochemistry, and plant molecular biology courses to plant cell biology. This integration see more attempts to break down the barrier so plant cell biology is seen as an entrée into higher science.

Distinguishing this book from papers that are often used for teaching the subject which use a single plant to demonstrate the techniques of molecular biology, this book covers all aspects of plant cell biology without emphasizing any one plant, organelle, molecule, or technique. Although most examples are biased towards plants, basic similarities between all living eukaryotic cells (animal and plant) are recognized and used to best illustrate for students cell processes.
Thoroughly explains the physiological underpinnings of biological processes to bring original insight related to plantsIncludes examples throughout from physics, chemistry, geology, and biology to bring understanding to plant cell development, growth, chemistry and diseasesProvides the essential tools for students to be able to evaluate and assess the mechanisms involved in cell growth, chromosome motion, membrane trafficking, and energy exchangeCompanion Web site provides support for all plant cell biology courses

por Gerald Karp

Designed for courses in Cell Biology offered at the Sophomore/Junior level, Karp's Cell and Molecular Biology continues to be the best book in the market at connecting key concepts to the experiments that reveal how we know what we know in the world of Cell Biology. This classic text explores core concepts in considerable depth, often adding experimental detail. It is written in an inviting style and at mid-length, to assist students in managing the plethora of details encountered in the see more Cell Biology course.  In this edition, two new co-authors take the helm and help to expand upon the hallmark strengths of the book, update and integrate text and media in a useful way, improving the student learning experience.

por John Wilson

The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be

por Stephen R. Bolsover

This text tells the story of cells as the units of life in a colorful and student-friendly manner, taking an "essentials only" approach. By using the successful model of previously published "Short Courses," this text succeeds in conveying the key points without overburdening the reader with secondary information. The authors (all active researchers and educators) skillfully present concepts by illustrating them with clear diagrams and examples from current research. Special see more boxed sections focus on the importance of cell biology in medicine and industry today. This text is completely updated from the successful "Cell Biology, A Short Course, 2e," includes new chapters and now has a supporting website with tests and animations for students and power point slides and supplemental material for instructors: http://www.wileyshortcourse.com/cellbiology/default.asp

por Ron Milo

A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

por Steven R. Goodman

Medical Cell Biology, Third Edition, focuses on the scientific aspects of cell biology important to medical students, dental students, veterinary students, and prehealth undergraduates. With its National Board-type questions, this book is specifically designed to prepare students for this exam. The book maintains a concise focus on eukaryotic cell biology as it relates to human and animal disease, all within a manageable 300-page format. This is accomplished by explaining general cell biology see more principles in the context of organ systems and disease.
This updated version contains 60% new material and all new clinical cases. New topics include apoptosis and cell death from a neural perspective; signal transduction as it relates to normal and abnormal heart function; and cell cycle and cell division related to cancer biology.
60% New Material!New Topics include: Apoptosis and cell dealth from a neural perspectiveSignal transduction as it relates to normal and abnormal heart functionCell cycle and cell division related to cancer biologyAll new clinical cases Serves as a prep guide to the National Medical Board Exam with sample board-style questions (using Exam Master(R) technology): www.exammaster.com Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students

por Antonio Lentini

T helper cells play a central role in orchestrating immune responses in humans. Upon encountering a foreign antigen, T helper cells are activated followed by a differentiation process where the cells are specialised to help combating the infection. Dysregulation of T helper cell activation, differentiation and function has been implicated in numerous diseases, including autoimmunity and cancer. Whereas gene-regulatory networks help drive T-cell differentiation, acquisition of stable cell states see more require heritable epigenetic signals, such as DNA methylation. Indeed, the establishment of DNA methylation patterns is a key part of appropriate T-cell differentiation but how this is regulated over time remains unknown. Methylation can be directly attached to cytosine residues in DNA to form 5-methylcytosine (5mC) but the removal of DNA methylation requires multiple enzymatic reactions, commonly initiated by the conversion into 5-hydroxymethylcytosine (5hmC), thus creating a highly complex regulatory system. This thesis aimed to investigate how DNA methylation is dynamically regulated during T-cell differentiation.To this end, we employed large-scale profiling techniques combining gene expression as well as genome-wide 5mC and 5hmC measurements to construct a time-series model of epigenetic regulation of differentiation. This revealed that early T-cell activation was accompanied by extensive genome-wide deposition of 5hmC which resulted in demethylation upon proliferation. Early DNA methylation remodelling through 5hmC was not only indicative of demethylation events during T-cell differentiation but also marked changes persisting longterm in memory T-cell subsets. These results suggest that priming of epigenetic landscapes in T-cells is initiated during early activation events, preceding any establishment of a stable lineage, which are then maintained throughout the cells lifespan. The regions undergoing remodelling were also highly enriched for genetic variants in autoimmune diseases which we show to be functional through disruption of protein binding. These variants could potentially disrupt gene-regulatory networks and the establishment of epigenetic priming, highlighting the complex interplay between genetic and epigenetic layers. In the course of this work, we discovered that a commonly used technique to study genome-wide DNA modifications, DNA immunoprecipitation (DIP)-seq, had a false discovery rate between 50-99% depending on the modification and cell type being assayed. This represented inherent technical errors related to the use of antibodies resulting in off-target binding of repetitive sequences lacking any DNA modifications. These sequences are common in mammalian genomes making robust detection of rare DNA modifications very difficult due to the high background signals. However, offtarget binding could easily be controlled for using a non-specific antibody control which greatly improved data quality and biological insight of the data. Although future studies are advised to use alternative methods where available, error correction is an acceptable alternative which will help fuel new discoveries through the removal of extensive background signals.
Taken together, this thesis shows how integrative use of high-resolution epigenomic data can be used to study complex biological systems over time as well as how these techniques can be systematically characterised to identify and correct errors resulting in improved detection.

por Baby Professor

At seventh grade, your child will become very busy with school lessons and extra-curricular activities. You can help your child breeze through his lessons on cell biology by giving him a copy of this educational resource. This book combines texts and pictures to make learning as pleasant and effective as possible. Go ahead and grab a copy today.

por Cell Press

Written by leading cell biologists and curated by Cell Press editors, reviews in the Cell Press Reviews: Core Concepts in Cell Biology publication informs, inspires, and connects cell biologists at all stages in their careers with timely, comprehensive insight into the most recent exciting developments across cell biology and hot topics within core areas of the field including: Signaling mechanisms and membrane biologyCytoskeletal self-organization and cell polarityOrganelle dynamics and see more biogenesisMorphogenesis and cell motilityChromatin and genome organization in nuclear function Contributions come from leading voices in cell biology, who are defining the future of their field, including: - Tom Misteli, National Cancer Institute - Galit Lahav, Harvard Medical School - Scott D. Emr, Cornell University - David G. Drubin, University of California, Berkeley - Tom Rapoport, Harvard Medical School - Anthony A. Hyman, Max Planck Institute of Molecular and Cell Biology, Dresden
This publication is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.
Provides timely, comprehensive coverage across a broad range of cell biological topicsOffers foundational knowledge and expert insights to students and others new to the fieldFeatures reviews from leaders in cell biology research and discussion of future directions for the fieldIncludes articles originally published in Cell, Current Biology, Developmental Cell, and Trends in Cell Biology

por Thomas D. Pollard

The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today’s students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their see more study time. Clearly written format incorporates rich illustrations, diagrams, and charts.Uses real examples to illustrate key cell biology concepts.Includes beneficial cell physiology coverage.Clinically oriented text relates cell biology to pathophysiology and medicine.Takes a mechanistic approach to molecular processes.Major new didactic chapter flow leads with the latest on genome organization, gene expression and RNA processing.Boasts exciting new content including the evolutionary origin of eukaryotes, super resolution fluorescence microscopy, cryo-electron microscopy, gene editing by CRISPR/Cas9, contributions of high throughput DNA sequencing to understand genome organization and gene expression, microRNAs, IncRNAs, membrane-shaping proteins, organelle-organelle contact sites, microbiota, autophagy, ERAD, motor protein mechanisms, stem cells, and cell cycle regulation. Features specially expanded coverage of genome sequencing and regulation, endocytosis, cancer genomics, the cytoskeleton, DNA damage response, necroptosis, and RNA processing. Includes hundreds of new and updated diagrams and micrographs, plus fifty new protein and RNA structures to explain molecular mechanisms in unprecedented detail.